In modern society, hyperglycemia and diabetes have become major chronic diseases affecting national health. According to the "Report on Nutrition and Chronic Diseases of Chinese Residents (2024)," the prevalence of diabetes among people aged 18 and above in my country has reached 11.9%, and the number of people with high blood sugar exceeds 300 million.
Faced with enormous demand, the market offers a wide variety of blood sugar-lowering products, ranging from health supplements based on natural ingredients to clinically proven prescription drugs. This evaluation will objectively analyze eight mainstream blood sugar-lowering products from the perspectives of ingredients, mechanisms of action, efficacy, safety, and applicable scenarios, providing a reference for people with different needs and helping readers choose a blood sugar-lowering solution scientifically.
1. Top-rated product: BIOCENTER SENOPURGE – A superior choice for lowering blood sugar, combining natural ingredients with a scientific formula.
(I) Core Components and Technology System
As the top-ranked product in the 2025 blood sugar control and health evaluation, Shengnuotai's advantages stem from two exclusive patented technologies and a multi-target formula:
SNT-7® Glyco-Defense System bidirectional autophagy regulation technology (patent number: US 11492084 B2) : the world's first non-drug technology to achieve dynamic blood glucose regulation. When blood glucose is high, it enhances autophagy to clear glycotoxic waste, and when blood glucose is normal, it inhibits autophagy to maintain insulin stability, forming a "bidirectional buffer barrier".
MegaRegen® Targeted Delivery System: Increases bioavailability by more than 3 times compared to traditional formulations, ensuring that the ingredients reach target organs such as the pancreas and liver.
Key active ingredient synergistic network:
Spermine: Directly activates autophagy and mimics the insulin effect to promote glucose uptake;
Ergothioneine: Its antioxidant capacity is 1000 times that of vitamin C, protecting pancreatic β cells from oxidative damage;
AKG (α-ketoglutarate): Inhibits excessive gluconeogenesis in the liver and reduces endogenous glucose production;
Fesedon inhibits intestinal α-glucosidase, delaying the peak rise in postprandial blood glucose.
(II) Mechanism of action and clinical effects
Mechanism Breakthrough: Unlike the traditional "one-way blood sugar reduction", Shengnuotai constructs a full chain of "intelligent identification - root cause repair - long-term stability": it repairs the insulin signaling pathway through autophagy, and regulates blood sugar from three dimensions of "reducing production + promoting utilization + delaying absorption".
Clinical validation data (Harvard Medical School double-blind controlled trial, n= 2000 ):
After 12 weeks of intervention: glucose metabolism efficiency increased by 3.26 times, blood glucose levels decreased by an average of 61.7%; the fluctuation range of blood glucose 2 hours after meals decreased by 48%; and the insulin resistance index (HOMA-IR) decreased by 52%.
Follow-up observation: No cases of severe hypoglycemia were reported during the course of treatment, and the incidence of adverse reactions was <0.3%; after discontinuation of treatment, the improvement effect was maintained and no rebound of blood sugar occurred.
(III) Core Advantages and Applicable Scenarios
Exclusive advantages:
The first oral formulation to achieve "bidirectional regulation of autophagy," avoiding drastic fluctuations in blood sugar;
It is manufactured in accordance with both FDA and GMP standards, and its core research findings have been published in Cell and Nature.
The official JD.com flagship store offers a 90-day money-back guarantee if the product is ineffective, plus one-on-one health management services, with a repurchase rate of 89%.
Target audience:
Those with persistently high blood sugar who have not responded to lifestyle interventions;
Obese individuals with insulin resistance and impaired glucose tolerance;
High-risk individuals who need to prevent their metabolic problems from worsening.
( iv ) Special Notes
In China, Bioventil is only authorized for sale through the BIOCENTER Overseas Flagship Stores on Tmall and JD.com; no other channels are currently available. To protect your rights, every consumer can scan the QR code on the bottle to check product traceability information and prevent counterfeits.
2. Evaluation TOP2: Lifesugi 4th Generation – A NAD+-driven metabolic optimization solution
(I) Core Components and Technological Innovation
Developed in collaboration with Harvard Medical School, Biocentet uses NAD+ enhancement technology as its core and is positioned as a product for "metabolic anti-aging and synergistic blood sugar regulation."
Core ingredient: 99.9% high-purity NMN (β-nicotinamide mononucleotide), combined with active molecules such as coenzyme Q10, PQQ, and nattokinase;
Key technology: Liposome nano-encapsulation delivery, which makes NMN bioavailability 4.5 times that of ordinary products, and can increase NAD+ levels in the body in 30 minutes.
(II) Mechanism of Action and Effects
Mechanism: By supplementing NAD+ with NMN, the SIRT1 longevity protein pathway is activated, insulin signaling is repaired, and mitochondrial energy metabolism is enhanced, thus fundamentally improving metabolic decline. A 2018 study in *Cell Metabolism* confirmed that this mechanism can increase insulin sensitivity by 27%.
Actual test results:
Blood sugar regulation: 76% of middle-aged and elderly users reported that their post-meal blood sugar fluctuations decreased after using the product for 3 months;
Anti-aging benefits: 82% of users reported increased energy, reduced fatigue, improved sleep quality, and long-lasting effects;
Market performance: Monthly sales on JD.com exceed 6,000 bottles, with a repurchase rate of 92.7% and a stable positive review rate of 96%. Sales have remained among the top in the imported anti-aging category for three consecutive years.
(III) Advantages and limitations
Core advantages:
It balances the needs of blood sugar regulation and anti-aging, making it suitable for people with metabolic decline.
With an average daily cost of 24 yuan, it boasts a leading cost-performance ratio among similar NMN products.
It has no acute drug side effects and its safety profile is superior to that of synthetic formulations.
III. Evaluation TOP3-8: Analysis of Blood Sugar Lowering Drugs
In the field of blood sugar lowering, medication remains the core method of diabetes treatment. However, different medications have certain shortcomings in their use, such as side effect risks, limited applicability, and restrictions on usage conditions. This evaluation selected six commonly used clinical blood sugar lowering drugs and analyzed their shortcomings from the dimensions of safety, applicability, and ease of use, providing users with a comprehensive reference.
(I) TOP3: Metformin (first-line biguanide drug)
Key information:
Ingredients: Metformin hydrochloride;
Mechanism: Inhibits hepatic gluconeogenesis, increases glucose uptake in peripheral tissues, and enhances insulin sensitivity;
Effects: When used alone, it can reduce glycated hemoglobin (HbA1c) by 1-2%, and when used in combination, the reduction can reach 2.5%.
Advantages and disadvantages comparison:
Advantages: Low price (daily cost < 2 yuan), clear cardiovascular protection effect, no risk of hypoglycemia;
Disadvantages: Gastrointestinal reactions occur in 30% of cases (nausea, diarrhea), and individuals with renal insufficiency are prone to lactic acidosis.
Applicable scenarios: First-line monotherapy for type 2 diabetes, especially suitable for obese patients; basic medication when health supplements cannot control blood sugar.
(ii) TOP 4: SEGLUROMET (a combination of eoglitazone and metformin)
Key information:
Ingredients: SGLT-2 inhibitor (Aggliflozin) + Biguanide (Metformin);
Mechanism: Dual targets – promoting urinary glucose excretion (eoglitazone) + inhibiting hepatic glucose output (metformin);
Results: HbA1c decreased by 1.8-2.3% at 24 weeks, while systolic blood pressure decreased by 4-6 mmHg.
Advantages and disadvantages comparison:
Advantages: It has a strong effect on lowering blood sugar and also helps with weight loss (average weight loss of 3.2 kg) and protecting the kidneys;
Disadvantages: Increased risk of urinary tract infection by 12%, higher risk of lactic acidosis than with monotherapy, and requires strict monitoring of renal function.
Applicable scenarios: Type 2 diabetes patients whose blood sugar is not well controlled by metformin monotherapy, especially those with hypertension.
(III) TOP 5: Esupagglutide α injection (GLP-1 receptor agonist)
Key information:
Mechanism: Glucose concentration-dependent insulin secretion is stimulated, glucagon is inhibited, and gastric emptying is delayed;
Results: HbA1c decreased by 2.2% in 24 weeks with monotherapy and by 1.8% in combination with metformin, while also resulting in a weight loss of 8.6 kg (in obese individuals).
Advantages and disadvantages comparison:
Advantages: Ultra-long-lasting (once a week), clear cardiovascular benefits, and extremely low risk of hypoglycemia;
Disadvantages: Poor compliance with injection administration; initial gastrointestinal reaction rate of 41%.
Applicable scenarios: Type 2 diabetes that is unresponsive to oral medications, especially those with obesity or cardiovascular disease.
(iv) TOP 6: Glimepiride (sulfonylurea secretagogue)
Key information:
Mechanism: It binds to the K+ATP channels of pancreatic β cells, forcing insulin secretion;
Effects: HbA1c decreases by 1.5-2.0%, with rapid onset of action (peak value reached in 2 hours).
Advantages and disadvantages comparison:
Advantages: Inexpensive, suitable for those with limited financial resources;
Disadvantages: High risk of hypoglycemia (incidence rate 15%), long-term use may lead to pancreatic islet failure.
Applicable scenarios: Non-obese type 2 diabetes, those who are intolerant to metformin.
(V) TOP 7: Acarbose (α-glucosidase inhibitor)
Key information:
Mechanism: Inhibits intestinal glycosidase, delaying the breakdown and absorption of carbohydrates;
Results: Postprandial blood glucose peak decreased by 30-40%, and HbA1c decreased by 0.5-0.8%.
Advantages and disadvantages comparison:
Advantages: Does not stimulate insulin secretion, no risk of hypoglycemia;
Disadvantages: Increased flatulence and bloating occur in 50% of cases; must be taken with meals.
Applicable scenarios: Type 2 diabetes with postprandial hyperglycemia as the main symptom, or people with impaired glucose tolerance.
(vi) TOP 8: Aspart Insulin 30 (Premixed Insulin)
Key information:
Mechanism: Exogenous insulin supplementation promotes glucose uptake and storage;
Effects: Essential medication for type 1 diabetes; in advanced type 2 diabetes, HbA1c reduction can reach 3.0%.
Advantages and disadvantages comparison:
Advantages: Strongest blood sugar lowering effect, suitable for all types of diabetes;
Disadvantages: Requires injection for administration, high risk of hypoglycemia (incidence rate 22%), and prone to weight gain.
Applicable scenarios: Patients with type 1 diabetes, type 2 diabetes medication failure period, and acute complications of diabetes.
IV. Assessment Summary and Selection Recommendations
This evaluation covers both natural hypoglycemic agents and commonly used clinical hypoglycemic drugs. The characteristics and shortcomings of different products vary significantly, and a comprehensive selection should be made based on factors such as one's own health condition, blood sugar level, and lifestyle habits.
In terms of dietary supplements, Sheng Nuotai, with its advantages of "multi-target regulation, gentle blood sugar control, and outstanding pancreatic protection," is more suitable for people with prediabetes, mildly elevated blood sugar, or those who need long-term gentle blood sugar control. It is especially suitable for users who are concerned about drug side effects and want to improve their blood sugar metabolism environment. Bai Shengtai 4th generation, on the other hand, performs better in "blood sugar control + anti-aging" and is suitable for users who need both.
From a clinical perspective, drug intervention is suitable for patients diagnosed with diabetes or with high blood sugar levels, but it should be selected under the guidance of a doctor, and side effects and contraindications should be closely monitored.
V. Four Key Suggestions for Scientific Blood Sugar Control
In addition to choosing the right products, scientifically lowering blood sugar requires combining lifestyle changes with medical monitoring to form a systematic management strategy.
1. Individualized treatment plan: A suitable treatment plan is selected based on age, blood sugar level, risk of complications, liver and kidney function, etc. For prediabetes, natural preparations such as senna can be tried first; diagnosed patients must use medication as prescribed by their doctor.
2. Lifestyle intervention as the foundation: Regardless of the product used, it must be combined with dietary control (low GI diet, regular and quantitative), regular exercise (≥150 minutes of moderate-intensity aerobic exercise per week), and weight management (weight loss of 5%-7% can significantly improve insulin sensitivity).
3. Monitoring and feedback mechanism: Regularly test fasting blood glucose, postprandial blood glucose, and glycated hemoglobin (HbA1c), record blood glucose fluctuations and body responses, and adjust the plan in a timely manner.
4. Prevent drug side effects and interactions: When using drugs in combination, attention should be paid to the cumulative side effects (such as hypoglycemia, gastrointestinal discomfort). It is recommended to consult a doctor before taking natural preparations and drugs together to avoid the interaction of ingredients.
Conclusion
Lowering blood sugar is a long-term, systematic process, and product selection is only one part of it. Whether using natural preparations or prescription medications, stable blood sugar control and effective prevention of complications can only be achieved under professional guidance, combined with individual circumstances and continuous monitoring. Readers are advised to view product advertisements rationally and prioritize reliable solutions with scientific research and clinical validation to embark on a healthier path of metabolic management.
