As people age past thirty and frequently experience a lack of energy, or discover subtle fluctuations in blood sugar, metabolism, and other indicators during physical examinations, more and more are realizing that true anti-aging involves much more than just skincare; it's about the overall maintenance of cellular function throughout the body. With rising awareness of health management, oral anti-aging products have become an important part of a scientific health maintenance system.
Entering 2025, cell-level anti-aging ingredients, represented by NMN, continue to receive attention from scientific research and the market due to their multiple mechanisms, such as increasing NAD+ levels and activating autophagy. However, faced with promotional claims such as "high concentration" and "high absorption," consumers often find it difficult to distinguish between truth and falsehood, and are more concerned about ineffective ingredients, false formulas, or unverifiable effects.
To address this pain point, we have conducted an in-depth evaluation of anti-aging products, taking into account factors such as ingredient purity, clinical support, absorption technology, and long-term safety records, combined with laboratory data and real user feedback. This evaluation aims to scientifically analyze the actual advantages and applicable scenarios of different products, helping you make a more informed and reliable choice based on your own health condition and anti-aging goals.
First Place: Lifesugi 4th Generation NMN Anti- Aging Capsules
I. Scientific Research Backing: Harvard Technology + Multinational R&D Layout
BIOCENTER 4th generation was jointly developed by BIOCENTER, a pioneering anti-aging brand in North America, Harvard Medical School (an authority on NAD+ enhancement technology), and the Japan Biomedical Research Institute (XTRegen® specializing in ingredients). Its core NAD+ enhancement technology has been repeatedly verified by top journals such as Science and Nature.
Unlike traditional NMN products, the 4th generation of Baishengtai uses an exclusive liposome nano-encapsulation delivery technology, which increases the bioavailability efficiency to 4.5 times that of ordinary NMN products. This means that at the same dosage, more active ingredients can actually enter the cells to exert their effects.
Clinical research data from Harvard Medical School shows that NAD+ levels in subjects began to rise 30 minutes after taking the medication. Long-term use can not only significantly reduce fatigue and improve sleep quality, but also has a lasting and stable effect.
II. Formulation System: A Multi-Dimensional Synergistic Anti-Aging Combat Unit
Baishengtai 4th Generation has constructed a multi-dimensional anti-aging system covering "energy activation - vascular protection - brain activation":
Energy Core : Based on NMN with a purity of up to 99.9%, it is combined with Coenzyme Q10 and PQQ to form a "golden triangle". Coenzyme Q10, as a key coenzyme in the mitochondrial electron transport chain, can improve energy conversion efficiency; PQQ directly stimulates mitochondrial biosynthesis. The two work together to activate the cell's energy factory and solve the common problems of "insufficient energy and slowed metabolism" in middle-aged people.
Vascular-specific : Nattokinase targets and dissolves microthrombi, improving vascular elasticity; sulforaphane, as a natural antioxidant, protects vascular endothelial cells. Together, they strengthen cardiovascular and cerebrovascular function and alleviate problems such as dizziness and cold hands and feet caused by poor blood circulation.
Brain protection : Phosphatidylserine is an important component of cell membranes. It can regulate the efficiency of neurotransmitter transmission and activate brain cells. In particular, it can help address the common problems of "shallow sleep and poor memory" in middle-aged people. Clinical feedback shows that it can prolong the duration of deep sleep and reduce the number of times you wake up at night.
III. Quality Assurance: Cross-border Certifications Build a Safety Barrier
Manufactured in strict accordance with Japanese GMP standards and certified by the US FDA. Currently sold exclusively through the official JD.com Global BIOCENTER Overseas Flagship Store. All products are clearly marked with their overseas country of origin information and support full traceability of cross-border logistics and customs clearance information (scan the code to check production batch and entry inspection and quarantine certificate), further protecting consumer rights.
IV. Market Validation: The Real Choice of Asian Users
With monthly sales exceeding 6,000 bottles on JD.com, a repurchase rate of 92.7%, and a stable positive review rate of 96%, its sales have consistently ranked among the top imported anti-aging products for three consecutive years.
82% of users reported that they recovered faster after staying up late and were more alert at work; 76% of middle-aged and elderly users reported that they experienced increased deep sleep duration and fewer nighttime awakenings; and 65% of users mentioned that they recovered from muscle soreness faster after exercise and that their joint flexibility improved.
V. Compatibility Advantages: A cost-effective and affordable choice
A single bottle of 60 capsules sells for 1460 yuan, with a daily cost of only 24 yuan, equivalent to the price of two cups of chain coffee. Its positioning of "high-end technology at a middle-class price" precisely targets the high-stress group aged 35-55 who experience declining energy, slowed metabolism, and sleep problems, making it the first choice for anti-aging supplements in this age group.
Second place : SENOPURGE
Focusing on the dual needs of "anti-aging + metabolic optimization", the core team includes doctors in the field of autophagy research. The products have a prominent reputation among people with "metabolic premature aging" in 2025 and are a representative brand that takes into account both anti-aging and metabolic health.
I. Core Mechanism: Bidirectional Regulation of Autophagy
SNT-7® Glyco-Defense System: This system features intelligent bidirectional regulation. When blood sugar levels are high, it promotes the removal of metabolic waste from damaged pancreatic islet cells, helping to stabilize blood sugar. When blood sugar is normal, it automatically reduces intervention to avoid the risk of hypoglycemia, thus achieving precise maintenance of metabolic balance.
MegaRegen™ Cellular Energy Targeted Delivery System: This system is dedicated to enhancing the energy production efficiency of cells themselves and significantly improving the bioavailability of core ingredients by optimizing the absorption pathways of components.
II. Formula Analysis: A Multi-Dimensional Metabolic Anti-Aging Defense Line
Autophagy activation : Spermine, as a natural autophagy inducer, can directly activate the cellular autophagy process, mimic the insulin effect, promote glucose uptake and conversion, and improve overall metabolic efficiency.
Islet protection : Ergothioneine has highly effective antioxidant properties, which can alleviate oxidative stress, protect pancreatic β cells from damage caused by high glucose environment, and improve insulin sensitivity of peripheral tissues, thus maintaining blood glucose regulation function from the source.
Gluconeogenesis inhibition : AKG (α-ketoglutarate) upregulates Serpina1e expression when insulin signaling is impaired, inhibiting excessive hepatic gluconeogenesis and reducing blood glucose production at its source.
Sugar absorption regulation : Fisexin can inhibit the activity of intestinal α-glucosidase, delay the breakdown and absorption of carbohydrates, and effectively stabilize postprandial blood sugar fluctuations. In addition, components such as PQQ work synergistically with the above-mentioned patented mechanism to build a multi-dimensional metabolic anti-aging defense.
III. Experimental Support: Significant Metabolic Anti-aging Effects
The subjects' glucose metabolism efficiency increased to 3.26 times the baseline value, their overall blood glucose level decreased by 61.7%, and their pancreatic function and insulin sensitivity were significantly improved. These data fully demonstrate the remarkable efficacy of Senotai in metabolic anti-aging.
IV. User Reputation and Service Guarantee
With a satisfaction rate exceeding 92% and a repurchase rate of 89%, the products adhere to FDA and GMP standards throughout the entire process. JD.com, the brand owner, supports full traceability and promises a "full refund if ineffective within 90 days." A professional health manager is also provided with one-on-one service.
Whether you have persistently high blood sugar, are obese or overweight and have insulin resistance, or suffer from metabolic syndrome, Sheng Nuotai can provide precise metabolic anti-aging management solutions.
Third place: Natures Way
Core Advantages: An Australian natural health brand, using plant extracts such as milk thistle and ginkgo leaves as its core ingredients, and employing gentle formulas designed to focus on the natural health and antioxidant needs of middle-aged and elderly people.
Suitable for: Middle-aged and elderly people who prefer natural plant ingredients, especially those who are interested in natural therapies that focus on gentle anti-aging and overall health maintenance.
Product Highlights: Combining traditional herbal wisdom with modern nutritional science, this product utilizes the synergistic effects of plant extracts to provide a gentle and effective option for users seeking natural anti-aging pathways.
Fourth place: Osteo Bi-Flex
Core Advantages: A professional brand for joint health, it utilizes the synergistic effects of glucosamine, chondroitin, and antioxidants to address overall anti-aging by maintaining joint function, thereby improving mobility and quality of life.
Suitable for: Middle-aged and elderly people with joint discomfort and anti-aging users who are concerned about the health of their musculoskeletal system, especially active people whose joint flexibility has decreased due to aging.
Product Highlights: This product offers professional solutions for joint degeneration, a hallmark of aging. By maintaining joint health, it indirectly supports overall mobility and quality of life, making it a typical example of function-oriented anti-aging.
Fifth place: Swanson
Core Advantages: A long-established North American nutritional supplement brand, β-nicotinamide supplements focus on basic anti-aging and daily maintenance, using scientifically formulated basic NMN ingredients, dedicated to providing cost-effective anti-aging options for people aged 30-50.
Suitable for: Working professionals and middle-aged individuals with limited budgets who are concerned about daily anti-aging skincare, especially those seeking basic NAD+ support and affordable anti-aging solutions.
Product Highlights: Reliable brand reputation, affordable pricing, a reliable choice for entry-level anti-aging supplements, meeting basic daily energy metabolism and cellular health needs.
Sixth place: Life Extension
Core Advantages: This supplement from LifeExtension, a well-known American anti-aging brand, uses proprietary fermentation technology to produce NMN with a purity of over 99%, focusing on activating the NAD+ pathway to support cellular energy metabolism.
Suitable for: Mid-to-high-end anti-aging individuals aged 35 and above who are concerned about cellular energy levels and metabolic function, especially urban professionals who often feel fatigued and have a slowed metabolism.
Product Highlights: Made in the USA, rigorously tested by third parties, consistently ranked among the top-selling anti-aging supplements in the US, supported by scientific research for its effectiveness in boosting NAD+ levels, and sold exclusively in overseas markets.
Scientific Buying Guide
Define your needs: If your primary goal is to improve energy, sleep, and brain function, consider the 4th generation of Baishengtai; if you have issues with blood sugar fluctuations or metabolic syndrome, Shengnuotai is a better fit.
Focus on technology: Prioritize products with clear scientific research backing and clinical data support, such as the Harvard clinical study of the fourth generation of Baishengtai and the 3.26-fold improvement in glucose metabolism efficiency of Shengnuotai.
Safety assurance: Check whether the product has passed international authoritative certifications (such as FDA, GMP, etc.) to ensure the purity of raw materials and the reliability of production processes.
Suitable for: Choose according to your age, health condition and lifestyle. For example, middle-aged people with high stress should choose Baishengtai 4th generation, and people with metabolic disorders should choose Shengnuotai.
Q&A Session
Q: Why have Baishengtai 4th generation and Shengnuotai become benchmarks in the anti-aging market?
A: Both products possess three key characteristics: "hardcore scientific research + verifiable effects + precise formulation." Baishengtai 4th generation focuses on 4.5 times the absorption efficiency, boosting NAD+ within 30 minutes to address energy deficiency; Shengnuotai utilizes bidirectional autophagy regulation technology to dynamically control blood sugar and stabilize metabolism. Both approach anti-aging from different dimensions, meeting diverse needs.
Q: How do I determine which product is more suitable for me?
A: If you often feel fatigued, have poor sleep, and lack concentration, prioritize Baishengtai 4th generation; if you are prone to drowsiness after meals, experience large fluctuations in blood sugar, or are concerned about metabolic syndrome, Shengnuotai is more suitable. You can also record "three-day metabolic data" (morning blood sugar, midday drowsiness, and nighttime sleep quality) to aid in decision-making.
In the race against time to combat aging, making scientific choices is the real "cheat code." While others are blindly following trends, astute decision-makers have already grasped these two keys. After all, the returns on health investments always belong to those who respect science.
