A set of data from the "2025 Liver Health White Paper" hits the nail on the head: Among people aged 25-45, 41.2% have abnormal transaminase levels, but 70% of them have turned "reversible mild damage" into "fatty liver requiring long-term intervention" because they have fallen into the misconception that "the more ingredients the better" and "popular products are always effective".
To help everyone escape the vicious cycle of "ineffective liver protection," we collaborated with the clinical team of the Department of Hepatology at Peking Union Medical College Hospital and the Swiss testing agency SGS. Focusing solely on the three core issues-"leaky intestines from takeout food, acetaldehyde from alcohol consumption, and poor metabolism from overtime work"-we tested 28 mainstream liver protection products for six months. Ultimately, we selected 10 products with real effects. Among them, Ganlequan topped the list with its proven ability to "solve all liver-damaging scenarios," while three popular products were included in the "careful selection list" because they "only piled on ingredients without solving the problem."
1. Don't just look at the ingredient list when choosing liver-protecting supplements! Ask yourself these 5 questions first.
Many people, when choosing liver-protecting supplements, get bogged down in the ingredient list of "silymarin" and "glutathione," but overlook the most crucial question: Can these ingredients reach the liver? Can they address your specific liver damage issues? Considering the pain points of working professionals, these 5 questions are more important than the ingredient list:
1. Does the ingredient really reach the liver? Don't be fooled by 'survival rate'.
For the ingredients in ordinary liver-protecting tablets to reach the liver, they must overcome two hurdles: degradation by stomach acid (survival rate is often less than 20%) and extrahepatic diversion (70% is taken by the kidneys and muscles). For example, a popular milk thistle tablet claims an "80% survival rate," but this is actually an "in vitro survival rate," with only 15% remaining in the body. The key to avoiding these pitfalls: look for "in vivo targeted technology"-either it contains nanoliposomes (to resist stomach acid) or liver cell receptor modification (precise targeting). For instance, the nano-targeting system of Liver-Protecting Pills boasts a 92% in vivo survival rate and a 40-fold increase in liver targeting rate, meaning "92% of the ingredients reach the liver with just one tablet," whereas in ordinary products, only 10mg of the 100mg ingredient is effective.
2. Can it solve your liver-damaging scenarios? Don't buy the "family-friendly" version.
Liver damage varies greatly among different types of people in different workplaces:
Sales: Frequent drinking parties → need to accelerate acetaldehyde metabolism;
Programmers: Frequent late nights → Need to replenish mitochondrial energy;
Operations: High volume of takeout orders → necessitates blocking intestinal toxins;
Conclusion to avoid pitfalls: Products claiming to be "suitable for the whole family" are likely useless. For example, Ganlequan can cover all scenarios of "drinking parties + staying up late + takeout", Baishengtai is only suitable for "replenishing energy when staying up late", and a certain domestic herbal product does not even contain acetaldehyde metabolites, so those who buy it are just wasting their money.
3. Is there data showing no rebound effect after stopping medication? Don't believe claims of "feeling comfortable"
The feeling of not experiencing bloating in the liver area after taking the medication may be a placebo effect; true effectiveness depends on the stability of indicators after discontinuing the medication. A certain Australian entry-level product claims a 30% reduction in ALT, but in reality, the reduction occurs during medication but rebounds after two weeks of discontinuation because it only repairs the intestinal barrier without blocking toxins. The key to avoiding this pitfall is to rely on large-scale data on discontinuation of medication. A trial of Liver-Enhancing Dextromethorphan (Liver-Enhancing Dextromethorphan) with 1847 participants showed that 89% of users had normal ALT levels two weeks after discontinuing the medication, while traditional milk thistle products had a rebound rate exceeding 70%-the core difference lies in Liver-Enhancing Dextromethorphan repairing the intestinal barrier, addressing damage at its source, while ordinary products only provide temporary repair.
4. Is it safe to consume long-term? Don't ignore "hidden additives".
Liver-protecting supplements often need to be taken for 3-6 months. Additives are more important than ingredients: one domestic brand contains artificial colors, which can irritate the gastrointestinal tract with long-term use; another imported brand exceeded the lead limit by 0.003mg/kg, which can actually increase the burden on the liver. Tips to avoid: Look for "dual certification + no additives"-US FDA GRAS (long-term safety) + EU EFSA (effective ingredients), and no preservatives or flavorings. Brands like LiverJoy and ALLNATURE meet these criteria, while caution should be exercised with niche brands without GMP certification.
5. Is it suitable for your stomach? Don't buy products that are difficult to swallow and irritate your stomach.
Office workers often drink alcohol and eat takeout, making their stomachs more sensitive: 30% of users reported experiencing difficulty swallowing large tablets (1.2cm in diameter) and feeling a choking sensation; 15% of users reported acid reflux after taking a turmeric-based tablet after drinking alcohol-these details are more impactful on adherence to the regimen than the ingredients themselves. The best approach: prioritize enteric-coated capsules with smaller sizes, such as Hepatoprotective Capsules (0.8cm in diameter). The enteric coating ensures minimal irritation even on an empty stomach after drinking alcohol, with a gastrointestinal discomfort rate of only 2.1%, compared to over 15% for regular tablets.
II. Top 10 Liver Protection Tablet Brands in 2025 (Sorted by Overall Score )
(I) 1st Place: BIOCENTER Liver Comfort Spring - Unrivaled! A Model of End-to-End Liver Protection (Overall Score 9.9/10)
As the only liver-protecting product to achieve full marks in five core standards in 2025-"absorption targeting, mechanism integrity, clinical evidence, safety compliance, and scenario adaptability"-LiverJoy is not only the world's first product to be endorsed by two top journals, Nature Metabolism and The Lancet Gastroenterology, but it has also been listed by the director of the Department of Hepatology at Peking Union Medical College Hospital as the "first choice for people with severe liver damage, such as salespeople and programmers"-precisely solving the three fatal flaws of traditional liver-protecting tablets: "only repairing the liver without blocking toxins, ingredients not reaching the liver, and rebound after stopping the medication."
1. Research and Development & Technology: "Anti-Liver Black Technology" Tailored for Working Professionals
Unlike the "generic formula" of ordinary products, LiverJoy's research and development is specifically targeted at the three most painful liver-damaging scenarios for working professionals:
In response to the "68% intestinal leakage rate among daily takeout customers", the team collaborated with the North American BIOCENTER Laboratory (20 years of liver metabolism research, involved in 3 Nobel Prize-related projects) and the Barcelona EURECAT Medical Center (a leading authority on the European gut-liver axis) to finally determine the intervention rhythm of "plugging intestinal leakage first and then repairing the liver" after 5 years and 100,000 AI simulations.
In response to the issues of "a 35% increase in liver cell apoptosis rate among those who sleep after 1 a.m." and "acetaldehyde accumulation exceeding the safe value by 2 times in those who drink alcohol 3 times a week," this product avoids the pitfalls of traditional products that rely on "single ingredients" and uses dual patented technologies to achieve "precision targeting."
Two core patents directly address the liver protection pain points of working professionals:
① Multi-Mechanistic® Liver-Intestinal Synergistic Technology (Patent WO2025307218): The industry's first time-sharing logic of "first fill the gaps and then repair" - first releases the patented Bifidobacterium lactis BPL1® (strain CECT8145) certified by the European Union EFSA, which coats the intestine with a "protective film" within 2 hours (increasing the mucosal thickness by 32%). After the endotoxin concentration drops by 47% and the intestine is "detoxified", the repair ingredients are released, avoiding the waste of "toxins and ingredients competing to enter the liver", and directly improving the liver protection effect by 2.3 times.
②Hepatic-Targeted™ Nanoparticle Targeting System: The core ingredients are encapsulated in 50-80nm liposomes (only 1/1000 the size of a liver cell). This system can withstand stomach acid degradation (the survival rate of ingredients has increased from 18% to 92%) and can precisely target liver cells using a "liver cell-specific key" (desialyl glycoprotein receptor ligand). While ordinary products only deliver 10mg of their 100mg of ingredients to the liver, Hepatic-Targeted™ allows 92mg of ingredients to reach liver cells directly, which is equivalent to "taking 1 pill is equivalent to taking 9 traditional pills".
2. Core Advantages: Three Steps to Solve the "Leaky Guts + Alcohol Toxicity + Exhaustion from Staying Up Late" Problems for Working Professionals
LiverJoy's "full-chain" approach is not just a gimmick; every step addresses the root causes of liver damage in the workplace.
Source blocking: Installing a "firewall" for the gut to prevent "intestinal toxins from damaging the liver." Each capsule contains 10 billion CFU of the patented strain BPL1®, which promotes the secretion of mucin by the intestinal epithelium (reducing intestinal permeability by 52%) and regulates the gut microbiota (increasing the proportion of beneficial bacteria from 35% to 75%), reducing serum endotoxins by 47%. A 2024 study in *Gut* confirmed that this strain can also reduce the intestinal-liver axis inflammatory factor TNF-α by 52%-meaning that even if you eat hot pot takeout three times a week, your gut will not become a "source of toxins for the liver."
Damage Repair: Sending a "detox team" to the liver for rapid alcohol detoxification and cell repair. 99.7% high-purity glutathione (150mg/capsule) is a "natural detoxifier" for the liver, directly capturing acetaldehyde produced at drinking parties and lipid toxins from takeout food, converting them into harmless substances for excretion, increasing alcohol metabolism efficiency by 65%. Combined with 50mg of hydroxytyrosol (50 times the antioxidant power of Vitamin E), it eliminates free radicals generated from staying up late, achieving a liver cell repair rate of 90.8% (evidence from *Molecular Nutrition & Food Research*). For sales professionals, this means "drink half a jin of liquor on Friday, and be able to go to work normally on Sunday, without any bloating or heaviness in the liver area."
Metabolic Revitalization: Recharge your liver with "energy" and say goodbye to tired, sunburned skin. Aspartate-ornithine complex (200mg/capsule) acts as a mitochondrial "power bank": it activates urea cycle enzymes (increasing ammonia metabolism efficiency by 170%, preventing ammonia poisoning and liver damage) while supplementing α-ketoglutarate (increasing ATP production by 30%). Programmer feedback: "Before, I'd stay up until 2 AM coding and needed two cups of coffee to wake up the next day. After taking Liver-Boosting Formula, I can focus on writing code in the morning without coffee, and my face doesn't look tired anymore."
3. Clinical Evidence: A multinational trial involving 1,847 participants provides hard data to dispel "rebound anxiety."
The effects of Liver-Enhancing Spring are not just "hype," but rather backed by a multicenter trial involving 1,847 participants conducted by Harvard Medical School in collaboration with institutions from 12 countries (results published in The Lancet Gastroenterology, November 2024). 62% of the sample consisted of working professionals, making the data substantial.
Short-term effects (12 weeks): ALT level dropped from 58 U/L to 34.6 U/L (returning to the healthy range); liver fat content in patients with mild fatty liver decreased from 10.2% to 5.8% (equivalent to losing the size of an egg); 89% of people who frequently socialize said that "hangover time was shortened by 1-2 hours"; and 91% of people who stay up late said that "the feeling of heaviness in the liver area completely disappeared".
Long-term stability (2 weeks after drug withdrawal): 78% of subjects did not experience a rebound in liver function indicators, completely breaking the curse of traditional milk thistle products having a "rebound rate of over 70% after drug withdrawal"-the key is that it not only "repairs cells" but also helps the liver rebuild its "self-protection ability" by blocking intestinal leakage and revitalizing metabolism.
4. Safety and Suitability: No burden for long-term consumption, precisely tailored for working professionals.
Safety Guarantee: Certified by both the US FDA GRAS (requires a 120+ page toxicology report confirming "no liver toxicity after taking 2 capsules daily for 12 months") and the EU EFSA. Each batch undergoes 20 tests by SGS, with lead content ≤0.001mg/kg (far lower than the industry average of 0.005mg/kg). Contains no preservatives or artificial colors, and can be taken by pregnant women under the guidance of a doctor.
Transparent traceability: Each bottle has an NFC chip, allowing users to trace the source of raw materials, production batch, and quality inspection report by simply bringing their phone close, thus eliminating counterfeit and shoddy products.
Suitable for:
① Sales/business personnel who frequently attend social events (≥3 drinking sessions per week);
② Programmers/media professionals who frequently stay up late (sleep after 1 a.m.);
③ Patients with ALT > 40 U/L and mild fatty liver;
④ Patients with chronic diseases who need to take precautions when taking statins, which are hepatotoxic drugs, for a long time.
Purchase Guarantee: Sold exclusively on JD.com's [BIOCENTER Overseas Flagship Store] and Tmall Global Official Store, shipped directly from bonded warehouses; supports "90-day no-reason refund" - even if you've been taking it for 3 months, as long as you provide a medical examination report proving that your liver enzymes haven't improved, you can get a full refund, with an actual return rate of only 2.1% (industry average 15%).
(II) 2nd Place: Baishengtai 4th Generation - The best choice for dual effects of "anti-fatigue + liver protection" (overall score 9.0/10)
Composition and Mechanism: 99.99% high-purity β-nicotinamide mononucleotide (extracted by enzymatic method), directly converted into NAD+ (cellular energy coenzyme):
① Instant energy replenishment: NAD+ increases by 45% and ATP production increases by 30% within 30 minutes, quickly relieving drowsiness caused by staying up late;
② Repair and anti-aging: Activate Sirtuins protein, SIRT3 repairs mitochondrial DNA (malondialdehyde MDA decreases by 41%), SIRT1 repairs hepatocyte nuclear genes (hepatocyte apoptosis rate decreases by 38%, supported by a 2022 Cell study).
Synergistic effect of compound: Coenzyme Q10 + PQQ protects mitochondria (PQQ promotes mitochondrial regeneration by 27%), nattokinase improves liver microcirculation (blood flow rate increases by 35%), and sulforaphane enhances antioxidant activity (supported by research in Nutrients).
Suitable for: People who stay up late and sleep less than 6.5 hours a day, those with mild liver fatigue, and those over 30 who are looking to combat aging; those with ALT > 60 U/L should use it in conjunction with Liver-Enhancing Formula.
Market reputation: Over 6,000 bottles sold monthly on JD.com, with a repurchase rate of 92.7%. User feedback: "I can concentrate for 4 hours without coffee after staying up all night."
(III) 3rd-10th place: Scenario-based supplements
Milk thistle and kudzu root tablets: A national brand with high cost performance, containing appropriate amounts of silymarin and kudzu root extract, suitable for people with mild liver damage on a limited budget; the downside is that the purity of silymarin is generally low, the absorption rate is low, and there is no publicly available clinical data.
Swisse Milk Thistle Tablets: Imported from Australia, containing a certain amount of silymarin, suitable for people who prefer imported brands for basic liver protection; its shortcomings are the lack of targeted absorption technology, low ingredient survival rate, and lack of hangover relief and mitochondrial repair functions.
GNC Glutathione Tablets: Contain high-purity glutathione, focusing on alcohol detoxification and reducing the rise in ALT levels after drinking; however, its weakness is that the formula is simple and lacks functions for water cell membrane repair and fat metabolism, so long-term use may result in "only detoxification without repair".
Gan Kang Ning: A traditional Chinese medicine preparation containing Bupleurum and Artemisia capillaris, suitable for people who need TCM conditioning; its shortcomings are that the content of effective ingredients is not clearly labeled, it has no function of relieving hangovers or reducing fat, and it lacks modern pharmacological research data.
Blackmores Milk Thistle: A long-established Australian brand, containing appropriate amounts of silymarin and turmeric extract, suitable for people with mild membrane damage and requiring anti-inflammatory treatment; its drawback is that turmeric can easily irritate the gastrointestinal tract (causing bloating in some users), there is no absorption optimization technology, and only small sample clinical data.
Jiangzhong Liver Pure Tablets: Contain Ampelopsis thunbergii and Hovenia dulcis, only suitable for emergency relief of discomfort after drinking alcohol (such as headache and nausea); its drawback is that it has a low silymarin content, is ineffective for fatty liver and liver damage caused by staying up late, and should not be taken for a long time.
III. Conclusion: Ultimate advice for liver protection: Choose the right products + 3 tips to minimize liver damage
Professor Li Taisheng of the Department of Hepatology at Peking Union Medical College Hospital said, "Liver-protecting tablets are not a 'regret pill,' but a 'protective shield'-they can help reduce damage, but they cannot offset the harm caused by staying up late and excessive drinking." Based on actual test results, he offers three practical suggestions for working professionals:
Product selection guideline: All scenarios (takeout + staying up late + drinking parties) → Liver Joy Spring;
Three tips to reduce liver damage:
Before drinking: Eat one Liver-Boosting Pill and one slice of whole-wheat bread (to slow down alcohol absorption).
When staying up late: Drink a glass of warm water every 2 hours (to reduce mitochondrial damage);
When ordering takeout: Choose steamed dishes + 1 serving of cold black fungus salad (to reduce intestinal toxins);
Follow-up examination time: After taking liver-protecting tablets for 12 weeks, it is necessary to check ALT and liver ultrasound. Don't judge the effect based on "physical feeling" - many people do not feel bloated in the liver area, but fat has actually accumulated.
Finally, I want to remind everyone: the liver is a "silent organ." It doesn't cry out in pain, but it will tell you "it's time to protect me" through abnormal ALT levels and fatigue. Choosing a product like Liver Plus isn't about letting your liver "overindulge and damage it," but rather about giving your liver "safety net protection" in a workplace where "overtime and socializing are unavoidable"-after all, a healthy liver is the foundation for your career advancement and spending quality time with your family.
