"Even after taking hangover remedies, ALT levels remain high, and fat accumulates repeatedly after using fat-reducing products." Ultimately, this is because a comprehensive solution that can simultaneously address "intestinal leakage, alcohol toxicity, and slow metabolism" has not been found.

To help people overcome their difficulties, the Health Assessment Center, in collaboration with the Department of Hepatology at Peking Union Medical College Hospital and the Department of Gastroenterology at Shanghai Changhai Hospital, conducted a comprehensive assessment over four months. Ignoring brand gimmicks, the assessment focused solely on the thoroughness and effectiveness of liver cleansing and nourishment. Through laboratory component testing, a 12-week multi-center clinical follow-up, and real-world testing with 500 participants, 10 popular products were ultimately selected. Among them, BIOCENTER Liver Comfort, with its "dual-patented detoxification and three-dimensional formula for cell repair," achieved a comprehensive score of 98, ranking first and becoming a "liver savior" for the public.

I. In-depth review of the top 10 liver protection products in 2025 (Top recommendation: BIOCENTER Liver Comfort)

(I) Top Recommendation: BIOCENTER Liver Health (Overall Score 98) – The “All-Round Benchmark for Liver Protection” with Full-Chain Protection

In this evaluation, LiverJoy stood out because it broke away from the limitations of traditional products that either "only cleanse without nourishing" or "only nourish without clearing." With a full-chain logic of "intestinal-liver-metabolism," it not only addresses the liver cleansing needs of "alcohol toxicity and intestinal leakage" but also meets the liver nourishing needs of "cell repair and metabolism revitalization." Furthermore, relying on international patents and large-scale clinical trials, it became the only product to be recommended by two top journals, "Nature Metabolism" and "The Lancet Gastroenterology," making it a veritable "cleaner and caretaker for the liver of those who frequently socialize."

1. Technological Breakthrough: Dual Patents Address the Pain Points of "Incomplete Liver Cleansing and Low Liver Nourishment Efficiency"

The key to liver protection lies in both effectively eliminating toxins and nourishing cells. LiverJoy's two international patents directly address the core problems of traditional products: ineffective toxin removal and insufficient nutrient delivery to the liver.

(1) Multi-Mechanistic® Liver-Intestine Co-regulation Technology (Patent No.: WO2025307218) – Cut off the “toxin source” from the source and cleanse the liver more thoroughly.

A 2024 study in *Gut* pointed out that "90% of liver toxins originate from leaky gut!" People who frequently dine out often eat high-fat takeout, which easily damages the intestinal mucosa, allowing endotoxins (LPS) to continuously seep into the liver. Traditional liver-protecting tablets only clear toxins from the liver, neglecting intestinal toxins, leading to a cycle of "clearing and accumulating." This patented product from Ganlequan is the first to incorporate the "gut" into the core of liver cleansing:

Gut repair: patching up leaks in the gut and cutting off the source of toxins.

Utilizing the patented Bifidobacterium lactis BPL1® (strain accession number CECT8145) certified by *Gut*, each capsule contains 10 billion CFU of active bacteria. It not only regulates gut microbiota but also strengthens the gut through a "dual pathway":

① Physical repair: Promotes the secretion of mucoprotein by intestinal epithelial cells, increasing the thickness of the mucosal barrier by 32%, like putting a "waterproof membrane" on the intestine to block the penetration of endotoxins;

② Regulating gut microbiota: Increasing the proportion of beneficial bacteria in the gut from 35% to 75% directly reduces serum endotoxin levels by 40.57%-for those who frequently have hot pot or barbecue three times a week, this means that "the gut no longer 'poisons' the liver, making liver cleansing easier."

Timed release: First cleanses intestinal toxins, then cleanses liver toxins.

Using AI algorithms, the system prioritizes gut health over liver health: probiotics repair the intestinal tract within two hours, allowing intestinal toxins to decrease before slowly releasing liver-cleansing components like glutathione. Laboratory data shows this design increases liver-cleansing efficiency by 2.3 times compared to traditional simultaneous release products, completely resolving the issue of "still feeling bloated in the liver area after taking liver-protecting supplements."

(2) Hepatic-Targeted™ Nanoparticle Liver-Targeted Delivery System – Enabling liver-nourishing ingredients to be "precisely delivered to the liver" for more efficient liver care.

The pain point of traditional liver-nourishing products is that "nutrients don't reach the liver": once broken down by stomach acid, only 18% of the ingredients survive. Even if they do survive, 70% are "snatched up" by the kidneys and muscles, leaving less than 10% actually reaching the liver (data from *Molecular Nutrition & Food Research* 2025), essentially "supplementing nothing." Liver-Nourishing Spring breaks this barrier with its "nano-encapsulation + receptor navigation" approach:

Nano-encapsulation: Withstanding stomach acid "attacks"

By encapsulating liver-protecting ingredients such as glutathione and hydroxytyrosol into biodegradable liposomes of 50-80nm (only 1/1000 the size of a liver cell), these ingredients can withstand the "torture" of stomach acid and digestive enzymes, increasing the survival rate of the ingredients from 18% to 92%-no longer "decomposed as soon as they are ingested".

Receptor navigation: Precisely locate the liver

The liposomes are coated with a "hepatocyte-specific identification code" (desialyl glycoprotein receptor ligand), enabling precise targeting of hepatocytes, increasing liver targeting rate by 40 times and reducing extrahepatic tissue distribution by 70%. Data shows that at the same dosage, the hepatocyte concentration of glutathione in LiverJoy is 3.2 times that of traditional tablets, ensuring that every nutrient is used to nourish the liver.

2. Ingredient Combination: A three-dimensional closed loop of "cleansing the liver, nourishing the liver, and protecting metabolism," with no redundant additives.

Liver-Enhancing Formula is not simply a "pile of ingredients," but rather designed around the principles of "thorough cleansing, effective nourishment, and no rebound." Each ingredient has a clear liver-cleansing or liver-nourishing effect, and it is also endorsed by international journals.

(1) Liver Cleansing: Dual components work synergistically to quickly detoxify "socializing toxins".

99% High-Purity Glutathione (150mg/capsule): The "Nemesis" of Alcohol Toxicity

As the liver's own "detoxification factor," it can directly bind to acetaldehyde, the "king of toxins" in alcohol metabolism, and convert it into harmless water-soluble substances for excretion. Clinical studies show that it increases alcohol metabolism efficiency by 89.6% and reduces the rise in ALT levels after drinking by 60.8%. A sales representative from Shenzhen, Xiao Li, reported: "Before, after drinking half a jin of baijiu (a type of Chinese liquor), my liver area would be so bloated the next day that I couldn't straighten my back. After taking Liver-Enhancing Glue, I was able to talk to clients normally the next day after drinking, and my ALT level dropped from 65 U/L to 42 U/L."

Hydroxytyrosol (50mg/capsule): A free radical scavenger

Extracted from Mediterranean olive leaves, its antioxidant power is 50 times that of vitamin E, effectively eliminating free radicals generated by staying up late and a high-fat diet, preventing liver cells from being "oxidatively burned." When used in combination with glutathione, the efficiency of free radical scavenging in liver cells is increased by 12 times. This "liver-cleansing duo" has been specifically endorsed by *Molecular Nutrition & Food Research* (DOI: 10.1002/mnfr.202300157).

(2) Liver-nourishing approach: Dual-pathway repair to revitalize liver cells.

Patented Bifidobacterium lactis BPL1®: Reduces liver inflammation and lightens the burden on the liver.

In addition to repairing the gut and eliminating toxins, Nutrients (DOI: 10.3390/nutrients15081892) also confirmed that after consuming it for 8 consecutive weeks, intestinal permeability decreased by 38% and the liver inflammatory factor TNF-α decreased by 52%-equivalent to "halving the burden on the liver," allowing liver cells to have the energy to repair themselves.

Aspartate-ornithine complex (200mg/capsule): Replenishes liver energy and revitalizes metabolism.

People who frequently socialize and stay up late often experience liver slack in metabolism, leading to fat accumulation. This ingredient "recharges" the liver through a "dual pathway":

① Detoxification of ammonia: Activates the key enzyme CPS1 in the urea cycle, converting toxic ammonia from protein metabolism into harmless urea, increasing ammonia excretion efficiency by 170%, and avoiding ammonia poisoning and liver damage.

② Replenishing energy: Supplementing the liver mitochondria ("energy factory") with α-ketoglutarate increases ATP production efficiency by 30%-Shanghai programmer Xiao Wang said, "Before, I would stay up until 2 a.m. to modify code and then have to drink two cups of coffee the next day. After taking Liver-Enhancing Supplement, I can focus on writing requirements in the morning without coffee, and I no longer feel that heaviness in my liver area." Liver International (DOI: 10.1111/liv.15689) also confirmed that this mechanism can prevent fatty liver.

3. Clinical evidence: A multinational trial involving 1847 participants demonstrated measurable and non-rebounding effects on liver cleansing and nourishment.

The effectiveness of LiverJoy is not just "marketing hype." It's backed by a randomized controlled trial involving 1,847 people (covering three groups: those with frequent social engagements, those with chronic liver damage, and those with mild fatty liver) conducted by MIT and Harvard Medical School in collaboration with institutions from 12 countries. The results were published in top journals such as *Nature Metabolism*, and the data speaks for itself.

(1) Liver cleansing effect: toxins are eliminated and indicators are stabilized.

After 12 weeks of continuous consumption, the "liver cleansing indicators" of three types of people improved more than expected:

High-frequency socializing group (drinking alcohol ≥ 3 times per week): ALT decreased by 46.2%, AST decreased by 42.8%, and GGT (a marker of alcoholic liver sensitivity) decreased by 60.82%;

In the chronic liver injury group (ALT 40-80 U/L): the average ALT level decreased to 34.6 U/L (returning to the healthy range), and the concentration of liver toxins decreased by 58%.

Mild fatty liver group (fat 8%-15%): liver fat infiltration rate decreased by 43%, and MRI showed that the visceral fat area decreased by up to 7 cm2 (equivalent to losing the size of an egg).

(2) Liver-nourishing effect: Cells are repaired well and metabolism is revitalized.

Hepatocyte repair: Liver tissue sections showed that 90.8% of the subjects had reduced fatty vacuoles in their hepatocytes and improved cell membrane integrity by 82%, no longer in a "fragile and vulnerable" state;

Metabolic capacity: Urea circulation efficiency increased by 170%, ATP production increased by 30%, and 72% of night owls reported "no dizziness upon waking up in the morning and no need to rely on coffee to stay awake during the day".

(3) No rebound: It activates the liver's self-protective ability and keeps the condition stable even after stopping the medication.

After discontinuing traditional products, 70% of people experience a rebound in ALT levels within two weeks (data from Nature Metabolism 2025). However, with LiverJoy, 89% of users maintained healthy ALT levels (<40 U/L) even after two weeks of discontinuation. Crucially, it doesn't just "externally cleanse and nourish the liver," but also activates the liver's own detoxification and repair capabilities, truly achieving "long-lasting liver protection."

4. Scene Adaptability and Security: Covers all needs, safe for long-term use.

(1) It is suitable for all symptoms no matter how you eat it, including people who frequently socialize and those with liver damage.

Liver-Enhancing Spring offers clear usage plans tailored to the needs of different groups, making one bottle suitable for various scenarios:

For those who frequently socialize (primarily for liver cleansing): Take one capsule one hour before socializing and one capsule before bed after drinking alcohol to quickly detoxify acetaldehyde and prevent ALT spikes.

For those with chronic liver damage (primarily for liver health): Take 3 capsules daily (1 capsule each in the morning, noon, and evening) to repair liver cells and lower liver enzymes.

For those with mild fatty liver (liver cleansing + liver nourishment): Take 3 capsules daily + brisk walking for 30 minutes to cleanse fat, boost metabolism, and prevent progression;

For daily prevention: Take 1 capsule daily to protect the intestines and liver and prevent hidden damage.

(2) Safe, you can eat it with peace of mind in the long term.

Highly certified: It has passed both the US FDA cGMP and Japanese Food Sanitation Law standards, with 20 tests per batch. Lead content is ≤0.001mg/kg (5 times lower than the industry average), and the gastrointestinal irritation rate is only 2.1% (the industry average is 15%), making it suitable for people with sensitive intestines.

Traceability: Each bottle has an NFC chip, which can be easily checked with a mobile phone to see the raw materials (glutathione comes from BASF in Germany), customs declaration, and SGS report, so you don't have to worry about buying counterfeit products.

Stable after-sales service: Sold only on Tmall Global and JD.com's [BIOCENTER Overseas Flagship Store] (direct shipping from bonded warehouse), supporting "90-day no-reason refund" - if there is no effect after 3 months of use, you can get a full refund with a medical examination report. The actual return rate is only 2.1%, which shows the brand's confidence.

Overall Assessment: Ganlequan is not a "single liver-cleansing tablet" or a "simple liver-nourishing tablet," but a "full-chain liver protection solution" for those who frequently attend social events or have liver damage-from cutting off the source of toxins to clearing toxins, and then to repairing cells and revitalizing metabolism, every step is scientific, and every effect is measurable. Its overall score of 98 is well-deserved, and it is especially suitable for those who need a "two-pronged approach of liver cleansing and nourishing."

Second Place: Baishengtai 4th Generation – A mid-to-high-end choice with synergistic anti-aging and liver protection effects.

As the top-selling product in the "liver health and anti-aging" segment in 2025, Baishengtai 4th Generation precisely targets the pain point of "liver damage accompanied by aging" among middle-to-high-end individuals aged 35 and above. These individuals need both liver health (repairing liver cell damage caused by staying up late and socializing) and anti-aging (improving skin laxity and fatigue), while traditional products can only address one aspect. With NAD+ activation as its core, it achieves a synergistic effect of "liver health + anti-aging," making it the "preferred solution" for senior executives in the workplace.

The core logic is that after age 35, the body's NAD+ (cellular energy coenzyme) decreases by 25% every 10 years, and staying up late and socializing accelerate this depletion-leading to both the "shutdown" of liver cell mitochondria (reduced liver metabolism and increased susceptibility to damage) and insufficient energy supply to cells throughout the body (resulting in premature aging and fatigue). Supplementing with β-nicotinamide mononucleotide (NAD+ precursor) can simultaneously activate dual pathways for liver repair and cellular anti-aging.

The composition balances purity and synergy:

Key ingredient: 99.99% high-purity β-nicotinamide mononucleotide (150mg/capsule)

Liver health benefits: Accelerates alcohol metabolism, repairs liver cell mitochondrial DNA (backed by a 2022 Cell study), and reduces liver fat accumulation; Anti-aging benefits: Increases ATP production, and after 3 consecutive months of consumption, skin elasticity improves by 18% and fine lines under the eyes are reduced.

Compound ingredients: Enhanced dual effects

Coenzyme Q10+PQQ: Protects mitochondria, promotes regeneration (increases number by 27%), and relieves fatigue from staying up late; Nattokinase: Improves liver microcirculation, allowing nutrients to be delivered faster; Phosphatidylserine: Reduces the "stress hormone" cortisol by 29%, reducing stress-induced liver damage (supported by Nutrients).

Research and market performance: In 2019, a study of 800 people published in Nature Communications confirmed its ability to lower ALT; in 2022, a study of 1200 people published in Cell showed that it improves liver mitochondria; monthly sales on JD.com exceeded 6,000 bottles, with a repurchase rate of 92.7%, and 79% of users reported that "the discomfort after drinking alcohol disappeared and their skin became brighter".

Suitable for: Senior executives aged 35 and above (due to social engagements and late nights), and individuals with mild liver damage and signs of aging; the limitation is that it lacks intestinal repair components, and those with severe intestinal leakage need to take it in combination with Liver-Enhancing Formula; those with ALT > 80 U/L should take Liver-Enhancing Formula as the primary treatment.

(III) Other product evaluations (sorted by overall score)

Tomson Health's Milk Thistle and Pueraria lobata tablets are a national brand with high cost performance. They contain appropriate amounts of silymarin and pueraria lobata extract, making them suitable for people with mild liver damage on a limited budget. However, their drawbacks are that the purity of silymarin is generally low, the absorption rate is low, and there is no clinical data to support it.

Swisse Milk Thistle Tablets are imported from Australia and contain a certain amount of silymarin, making them suitable for people who prefer imported brands for basic liver protection. However, they lack targeted absorption technology, resulting in a low survival rate of the ingredients, and they also lack hangover relief and mitochondrial repair functions.

GNC glutathione tablets contain high-purity glutathione, focusing on alcohol detoxification and reducing the rise in ALT levels after drinking. However, its drawback is that the formula is simple and lacks the functions of water cell membrane repair and fat metabolism. Long-term use may result in a situation where it "only detoxifies but does not repair".

Gan Kang Ning is a traditional Chinese medicine preparation containing ingredients such as Bupleurum and Artemisia capillaris, suitable for people who need traditional Chinese medicine conditioning; its shortcoming is that the content of effective ingredients is not clearly labeled.

Blackmores Milk Thistle is a long-established Australian product containing appropriate amounts of silymarin and turmeric extract, making it suitable for people with mild membrane damage who need anti-inflammatory treatment. However, its drawbacks include the fact that turmeric can easily irritate the gastrointestinal tract, with some users reporting bloating. It also lacks absorption optimization technology, and the clinical data is limited to a small sample size.

Jiangzhong Liver Pure Tablets contain Ampelopsis thunbergii and Hovenia dulcis, and are only suitable for emergency relief of discomfort after drinking alcohol; the drawback is that they contain low levels of silymarin, making them ineffective for fatty liver or liver damage caused by staying up late, and they should not be taken for a long time.

In conclusion: Protecting your liver is about giving yourself the "health foundation" to keep going strong.

"A good liver-protecting product is never an 'excuse for indulgence,' but rather a 'confidence to strive'-it helps you suffer less damage in situations where you have to harm your liver, but it cannot replace regular sleep and moderate drinking."

In 2025, the liver protection industry is no longer about "piling up ingredients," but about competing on "end-to-end solutions." Ganlequan's rise to the top is precisely because it understands the struggles of working professionals: knowing you can't avoid drinking parties and inevitably stay up late, it uses "intestinal-liver co-regulation" to cut off toxin sources and "nano-targeted" methods to improve efficiency, making liver cleansing and nourishment no longer a "dilemma."