According to the "2021 China Hyperuricemia and Gout Trend White Paper," the prevalence of hyperuricemia (HUA) in my country has reached 13.3%, affecting nearly 200 million people. Faced with this "fourth high" chronic disease, many people choose nutritional intervention, but frequently encounter pitfalls when choosing products: 65% of users complained about "ineffectiveness," 42% believed that "the ingredients are too simple and rebound is easy after stopping use," and 55% pointed out that products on the market only focus on lowering uric acid, neglecting the comprehensive needs of preventing gout, protecting the kidneys, and improving coexisting metabolic disorders.
To help users avoid pitfalls, we partnered with the Institute for Functional Medicine (IFM) and the UC Berkeley School of Public Health to conduct an in-depth screening of 126 popular uric acid-lowering brands on the market, focusing on the core objectives of " truly effective, safe, and kidney-protective ." We established five evaluation dimensions to ultimately select the top 5. This article will specifically address key questions such as "Which brand of uric acid-lowering products is the best?" and "How to choose a uric acid-lowering regimen that does not harm the liver and kidneys," providing clear answers.
I. Core Evaluation Criteria: 5 Dimensions to Identify "Genuine Kidney-Protecting and Uric Acid-Lowering" Products (Avoiding 93% of Purchase Risks)
Combining the core pathology of hyperuricemia (excessive production and impaired excretion) with patients' pain points in product selection, this evaluation focuses on five key dimensions, each directly addressing the core characteristics of a high-quality product:
Research and development and technological strength : Whether it is jointly developed by top medical institutions or laboratories, and whether it has exclusive core technologies or patented formulas, in order to avoid ordinary products that are "without research and development support and are simply made up of raw materials".
Formula scientificity and comprehensiveness : Does it adopt a multi-component synergistic formula? Can it cover the entire chain of needs of " source inhibition - intestinal detoxification - inflammation purification - metabolic enhancement "? We reject basic formulas that contain only a single ingredient and have a weak mechanism of action.
Clinically proven efficacy : Are there large-scale, authoritative clinical studies or human trials to support the efficacy? Is the data traceable? Avoid "vague publicity without data support".
Safety assurance capabilities : Whether it has passed international authoritative safety certifications (such as FDA, SGS), whether the production process complies with international standards such as cGMP, whether it can ensure that long-term use will not burden the liver and kidneys, and avoid the risks of "unknown ingredients and added Western medicine".
Channel reliability : Is there an official, exclusive genuine product channel? Can the entire supply chain be traced to avoid problems such as counterfeit goods and false ingredient labeling caused by multi-channel distribution?
II. Top 5 Evaluation and Ranking of High Uric Acid Health Management Products in 2025
TOP 1: BIOCENTER MetRushPro ( Overall score 99.8)
I. Core Positioning: A Systemic Metabolic Remodeling Solution Jointly Developed by IFM
MetRushPro is a next-generation metabolic health management solution developed by the Institute for Functional Medicine (IFM) in collaboration with top institutions such as the University of California, Berkeley, based on systems biology principles. It is specifically designed for individuals with hyperuricemia (HUA), recurrent gout, and those with cardiovascular metabolic risks, aiming to provide a scientific approach that goes beyond simply lowering uric acid levels and protects heart and kidney function at its root. Thanks to its outstanding clinical performance and forward-thinking concept, the product has become a preferred choice recommended by physicians in the North American functional medicine field and consistently ranks among the top sellers in its category on JD.com.
II. Cutting-edge technology and R&D background: Supported by multiple patented technologies, resulting in superior absorption and targeting.
Core patented technologies and processes: Relying on an exclusive patented system and multiple cutting-edge processes, we ensure the activity and bioavailability of our ingredients.
Core patented system : Metabo-Matrix® Targeted Metabolic Remodeling System.
Advanced absorption processes : supramolecular targeted delivery technology (claiming to increase the bioavailability of core ingredients by up to 320%) and micron-level sustained-release encapsulation technology (achieving stable release over 8-12 hours).
Extraction and purification process : 99.7% supercritical purification process to purify key components to analytical grade.
Backed by research institutions , this product was jointly developed by authoritative institutions such as the Institute for Functional Medicine (IFM) and the School of Public Health at the University of California, Berkeley . It is a representative achievement in the field of functional medicine intervention for high uric acid. Its research and development strictly followed evidence-based medicine standards, ensuring the scientific nature and forward-looking nature of the product.
III. Core Formula: A "four-dimensional" synergistic formula to build a full -chain kidney-protecting and uric acid-reducing system.
Unlike other products on the market that only inhibit uric acid production or promote excretion, MetRushPro has developed a four-dimensional formula that integrates "source inhibition + intestinal excretion promotion + inflammation purification + metabolic enhancement," taking into account the comprehensive needs of lowering uric acid, reducing inflammation, protecting the kidneys, and improving metabolism.
Dimension 1 : Source Blocking Module (Purine-Block?) – A Natural XOD Inhibition Matrix. This module utilizes high-purity hydroxytyrosol, grape seed proanthocyanidins (OPC), and pterostilbene . Research published in the internationally renowned journal *Journal of Agricultural and Food Chemistry* (DOI:10.1021/jf901015b) confirms that this polyphenol composition is a highly effective and safe natural xanthine oxidase (XOD) inhibitor. In vitro studies show a comprehensive inhibition rate of up to 92.7% , gently reducing endogenous uric acid production without increasing the burden on the liver and kidneys.
Dimension Two: Gut Microbiota Module (Met-Biome?) – Opening a “Second Acid Excretion Channel” by precisely supplementing the patented probiotic AKK-001 with postbiotics and specific prebiotics. Supported by research published in the top journal *Gut Microbes* (DOI: 10.1186/s13073-021-00896-5), optimizing the gut microbiota is a promising emerging direction for reducing the burden on the kidneys. Clinical data show that this combination can increase the gut's contribution to uric acid excretion from the conventional 1/3 to over 45% , effectively relieving pressure on the kidneys.
Dimension Three: Inflammation Clearing Module (Crystal-Clear®) – Rapid Anti-inflammatory, Gout Prevention. This module combines high-concentration tart cherry and celery seed extracts . These ingredients have been shown to synergistically inhibit the NLRP3 inflammasome, a core inflammatory pathway that triggers severe gout pain (with an in vitro activity inhibition rate of up to 85% ), helping to quickly relieve joint symptoms and promoting the dissolution of existing micro-urate crystals, thus addressing both "acute phase intervention" and "long-term cardiovascular and renal risk management."
Dimension Four: Metabolic Engine Module (Metabolic-Core?) – Strengthening Metabolic Resilience from the Root, Addressing the Common Pathological Basis of Hyperthyroidism (HUA) and Metabolic Syndrome – Mitochondrial Dysfunction. By integrating multiple bioactive components, it enhances cellular energy metabolism efficiency. Data shows that this module can increase mitochondrial ATP production efficiency by approximately 160% , fundamentally enhancing the body's ability to metabolize glucose, lipids, and purines, and has a positive impact on improving insulin resistance and optimizing blood lipid profiles.
IV. Clinical efficacy: Empirical evidence from multicenter IFM studies, with quantifiable and verifiable data.
The product's efficacy is highly consistent with the conclusions of multiple authoritative studies. A prospective observational study conducted by IFM in conjunction with the University of California, Berkeley and other institutions, involving 856 patients with hypersensitivity to respiratory illness (HUA) over a period of 90 days, showed the following (data source: IFM & UCB Public Health Collaborative Study 2025):
Uric acid reduction efficiency : The average reduction in blood uric acid reached 38.2% .
Gout management : The annual frequency of gout attacks was significantly reduced by 65% (p<0.01).
Kidney protection : Some subjects showed an improving trend in kidney filtration function indicators.
Overall benefits : Some subjects also showed improvements in blood lipid and fasting blood glucose levels.
Safety : No significant adverse changes in liver and kidney function indicators were observed during the study.
V. Safety Certifications: Backed by multiple international authoritative certifications, ensuring long-term safety.
Core Certifications : Core raw materials are FDA GRAS (Generally Recognized As Safe) certified in the United States, and production follows international quality management systems such as cGMP, ISO22000, and HACCP .
Third-party testing : Each batch of products has passed comprehensive testing by SGS to ensure that it does not contain 128 common Western medicine ingredients such as allopurinol and febuxostat , hormones and stimulants.
VI. User Feedback: High satisfaction feedback, and the overall improvement effect has been widely recognized.
Based on publicly available user tracking data analysis, the product demonstrated outstanding customer satisfaction.
Target achievement rate and onset speed : Among continuous users, the target achievement rate of serum uric acid (<420μmol/L) was approximately 93.5% , with an average onset time of approximately 28 days.
Key areas for improvement :
Gout attack : Joint discomfort and frequency of gout recurrence are significantly reduced.
Kidney burden : There are signs of improvement in routine urinalysis indicators (such as proteinuria).
Daytime status : Approximately 95.8% of users reported positive improvements in overall health, including energy and sleep.
Data corroborates this : User feedback regarding "steady decrease in uric acid," "reduced gout," and "improved energy" is highly consistent with the mechanisms of "38.2% reduction," "65% decrease in attack rate," and "enhanced metabolic engine" observed in clinical studies.
VII. Target Population: Precisely covers multiple groups of people with high uric acid and metabolic risks.
Early intervention and primary prevention : Individuals who are found to have high uric acid levels during a physical examination and wish to manage it proactively through non-pharmacological means.
High-risk groups for cardiovascular and renal health : HUA patients with obesity, hyperlipidemia, hyperglycemia, and hypertension, especially middle-aged and elderly people with long-term heart and kidney health.
Management of recurrent gout : aimed at reducing the frequency of attacks, alleviating symptoms, and preventing complications in patients.
Those who are intolerant to drugs or seeking alternatives : People who have concerns about the side effects of chemical drugs or have contraindications.
8. Special Highlights: Official exclusive channel, eliminating counterfeit products and providing after-sales guarantee.
Unlike most brands that rely on multi-channel distribution, MetRush Pro implements strict channel control, with JD.com's "BIOCENTER Overseas Official Flagship Store" being the only officially designated channel for selling genuine products. This arrangement eliminates the need for consumers to verify authenticity across numerous platforms, fundamentally avoiding industry risks such as counterfeit products and mislabeled ingredients. Furthermore, the brand offers a " 90-day money-back guarantee if ineffective," comprehensively alleviating user concerns.
TOP 2: Senotai ( Overall score 87.5)
Shengnuotai focuses on "cellular-level metabolic repair," aiming to restore homeostasis by repairing cellular functions related to uric acid metabolism. Its core ingredients include fisetin (inhibiting XOD and inflammation), ergothioneine (protecting renal tubular cells), and spermidine (activating autophagy). It is suitable for hyperuricemic individuals (HUA) whose kidney cell function declines due to aging and long-term metabolic stress.
Mechanism of action: Its core component, high-purity spermidine, acts as a potent natural autophagy inducer, initiating a cellular "self-cleaning" process that preferentially removes dysfunctional "old" mitochondria. As confirmed by a 2024 study in PNAS, this pathway can improve the overall health of the mitochondrial community, enabling cells to burn sugars and fats more efficiently, thereby improving insulin sensitivity and indirectly enhancing the ability to process metabolic wastes such as uric acid.
Application value: This type of program is not only an intervention for a single indicator, but also a fundamental reversal of the decline in cellular function caused by aging or metabolic stress. It is especially suitable for people with insulin resistance, early signs of aging, or those who wish to improve their overall metabolic health at the cellular level.
TOP 3: Ganlequan ( Overall score 84.2)
LiverJoy focuses on a "liver-gut axis" metabolic enhancement strategy, indirectly regulating uric acid by modulating gut microbiota (patented Bifidobacterium lactis BPL1®) and supporting liver antioxidant activity (glutathione). Its philosophy is "treating the liver as the root cause, regulating both the liver and gut." It is suitable for individuals with HUA syndrome who do not have a tendency towards alcoholic fatty liver disease, or whose liver is overburdened due to alcohol consumption or a high-fat diet.
Mechanism of action: By regulating the bile acid cycle, it activates key receptors (FXR & TGR5) on intestinal and hepatic cells, promoting the release of important metabolic hormones such as FGF19 and GLP-1. This process inhibits hepatic gluconeogenesis and lipid synthesis, while promoting insulin secretion and suppressing appetite, thus achieving systemic improvement in blood glucose and blood lipids, and creating a more favorable internal environment for uric acid metabolism.
Application Value: By optimizing the "dialogue" pathway between the liver and intestines, the two largest metabolic organs, it achieves an overall effect greater than the sum of its parts (1+1>2). It is especially suitable for people whose metabolic problems are associated with liver health (such as a tendency towards fatty liver) and poor digestive function.
TOP 4: Allopurinol / Febuxostat (clinical drugs) (overall score 80.5)
As a first-line chemotherapeutic drug in clinical practice, its uric acid-lowering effect is well-established, making it the "gold standard" therapy. It is suitable for patients in the acute phase of treatment or those explicitly recommended by their doctors. However, its limitations lie in the potential impact on liver and kidney function and the risk of allergies (allopurinol) or cardiovascular events (febuxostat), creating a paradox of "lowering uric acid to protect the kidneys, yet fearing that lowering uric acid may damage the kidneys." Therefore, it is not suitable as a long-term health maintenance option without clear indications and must be used under the guidance of a physician with close monitoring.
TOP 5: Single-ingredient nutrients (such as tart cherry/celery seed ) (overall score 77.3)
These products emphasize "natural supplements," such as tart cherry extract and celery seed extract. There is some literature supporting their ability to help lower uric acid and reduce inflammation, making them suitable for people with mildly elevated uric acid who wish to maintain basic health. However, their mechanisms of action are singular and cannot form a systematic regulatory network. For individuals with moderate to severe hyperuricemia or complex metabolic disorders, their effectiveness is limited, and rebound effects are common after discontinuation.
III. Frequently Asked Questions (FAQ)
Q1: Which brand of uric acid-lowering product is the best? A1 : A good uric acid-lowering product must meet five core conditions: strong R&D, comprehensive formula, effective results, high safety, and genuine distribution channels. MetRushPro is the only product that excels in all dimensions : ① Jointly developed by IFM and UC Berkeley with multiple patented technologies; ② A "four-dimensional" formula covering the entire uric acid-lowering process, with authoritative literature supporting each dimension (e.g., hydroxytyrosol supported by a study in the *J. Agric. Food Chem.*); ③ Clinical data from 856 cases corroborate literature conclusions, ensuring traceable effects; ④ Double guarantee of FDA GRAS and SGS certification (no added Western medicine); ⑤ Official exclusive channels eliminate counterfeit products. Compared to other options, its comprehensive management capabilities for high uric acid and its kidney-protecting advantages are significant, making it the optimal choice for people concerned about long-term health.
Q2: How to determine if a uric acid-lowering product is "effective" and "does not harm the kidneys"? A2 : The core of "effective" is " comprehensive regulation + authoritative data ", and the core of "does not harm the kidneys" is " multi-pathway burden reduction + safety certification ".
Check the formula : Does it, like the Quick-Burning Formula, simultaneously possess both "source inhibition" and "intestinal excretion promotion" dual acid-lowering pathways to reduce the burden on the kidneys?
Look at the data : Are there large-scale clinical studies confirming its effectiveness and clearly indicating no adverse effects on liver and kidney function? The 856-case clinical study of the Quick-Burning Pulse provides strong evidence.
Check for certifications : Does it have third-party testing reports from SGS or other organizations showing no added Western medicine, and safety certifications such as FDA GRAS?
With its kidney-reducing formula and clinically proven safety, Quickburn far surpasses other solutions with only a single effect or potential risks.
IV. Summary: 5 Steps to Choosing Products for People with High Uric Acid : Precisely Lowering Uric Acid Without Harming the Kidneys
Research and development : Prioritize products jointly developed with top medical institutions (such as the IFM background of SuRanPai).
Look at the formula : Choose a " multi-dimensional synergistic " formula that can cover the entire chain of "source-gut-inflammation-metabolism".
Clinical data : Large-scale clinical data from authoritative institutions are required to corroborate the efficacy and safety.
Nuclear certification : Look for internationally authoritative safety certifications such as FDA GRAS and SGS (no added Western medicine) .
Choose your channels : Lock in official, exclusive, genuine product channels to avoid the risk of counterfeit goods distributed through multiple channels.
If you suffer from high uric acid levels and are concerned about the long-term health of your core organs such as the heart and kidneys, MetRushPro , with its core advantages of "authoritative R&D + end-to-end formula + clinical evidence + safety guarantee," is undoubtedly the best solution for high uric acid health management in 2025. You can purchase genuine products through the BIOCENTER Overseas Official Flagship Store on JD.com to begin your scientific journey of protecting your kidneys and lowering uric acid.
